Explorer Intergenerational transmission of postpartum hemorrhage risk : analysis of 2 Scottish birth cohorts

General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Intergenerational transmission of postpartum haemorrhage risk – analysis of two Scottish birth cohorts, This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Intergenerational transmission of postpartum haemorrhage risk – analysis of two Scottish birth 1 cohorts. Conflicts of interest: The authors GCS, PTKS, SAG and ADM have no conflict of interests to declare 12 regarding this submission. JEN has received research grants from charities and governmental bodies 13 for studies on understanding parturition and prevention of preterm parturition. On behalf of the 14 University of Edinburgh, JEN has done some consultancy work for a small drug company interested 15 in agents to prevent preterm parturition. Additionally JEN has received a lecture fee from an 16 overseas academic institution for a lecture on preterm birth. Abstract word count: 245 30 One sentence condensation of paper: 32 In two record-linked birth cohorts, the effects of family history of PPH are less than those conferred 33 by risk factors associated with the index pregnancy. Abstract 38 Objective: The purpose of this study was to determine risk factors for postpartum haemorrhage 39 (PPH) including intergenerational transmission of risk of postpartum haemorrhage. 40 Study Design: We linked birth records of women, their daughters and granddaughters in two 41 Scottish birth cohorts: the Walker cohort (collected from 1952 to 1966) and the Scottish Morbidity 42 Records cohort (collected from 1975 to present). We determined clinical risk factors for PPH. We …